A novel class of polymeric pH-responsive MRI CEST agents.
نویسندگان
چکیده
In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an acidic environment.
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عنوان ژورنال:
- Chemical communications
دوره 49 57 شماره
صفحات -
تاریخ انتشار 2013